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I had designed a t-shirt collection called the "Classic Wild" for a fly fishing company. The group included the brook, brown, cutthroat, and rainbow trout. These were all digitally drawn on the computer with a mouse. Yes, these were done on the computer before the pens and tablets were invented.
Side note: I am left-handed when I draw, but I use the mouse with my right-hand to draw on the computer. When I use a pen and tablet, I go back to drawing with my left hand.